Nodular glomerulosclerosis after renal transplantation without diabetes mellitus.

tissue contained 15 glomeruli with diffuse thickening Introduction of the glomerular basement membrane as well as increase in mesangial matrix in each. In addition, Nodular glomerulosclerosis is a well-described lesion mesangial hyaline nodular lesions were present in seven of diabetic nephropathy. Although it was considered glomeruli (Figure 1). No tubulointerstitial or vascular pathognomonic for this entity, nodular glomerulodamage was observed. Immunofluorescence staining sclerosis has been also reported in the absence of overt with Igs,C3,kappa and lambda light chains was negaglucose intolerance [1–6]. In addition, rare cases of de tive. Congo red staining for amyloid was also negative. nova nodular glomerulosclerosis have been reported in Electron-microscopy (tissue obtained from paraffin) patients who developed post-transplant diabetes melrevealed irregular, marked, uniform thickening of the litus [7]. basement membrane and increased mesangial matrix. The purpose of this paper is to describe a renal Immune deposits were absent (Figure 2). transplant patient with typical lesions of diabetic noduOne year later, the patient is normotensive. Serum lar glomerulosclerosis without past or present glucose creatinine is 5 mg/dl, proteinuria has ranged from 0.4 intolerance. to 4 g/day with normal total protein and serum albumin. Fasting blood glucose has remained normal. Case report